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KMID : 0603519980030020122
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Journal of Korean Association of Cancer Prevention
1998 Volume.3 No. 2 p.122 ~ p.127
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In vitro Anticancer Effects and the Mode of Action of Dichloromethane Fraction of Coix lachryma-jobi(adlay)
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Kim Seong-Joon
Choi Young-Hyun
Lee Won-Ho
Kwon Eun-Young
Park Kun-Young
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Abstract
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Anticancer effects and the mode of action of dichloromethane fraction from the methanol extract of defatted Coix lachryma-jobi(adlay) were studied. Adlay was defatted with hexane and extracted with methanol. The methanol soluble fraction of the defatted allay was further fractionated with dichloromethane, ethylacetate, butanol and water. Dichloromethane fraction that exhibited the highest antimutagenic and anticancer activities was chosen to investigate the further anticancer effects and the mode of action. Dichloromethane fraction inhibited the growth of MCF-7 and MDA-MB-231 human breast carcinoma cells and the morphological changes of the cancer cells were observed. Also, dichloromethane fraction arrested G2/M phase in the MCF-7 human breast carcinoma cell cycle and induced apoptosis of HL-60 human leukemia cells.
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KEYWORD
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Coix lachryma-jobi(adlay), Anticancer, Cell cycle, Apoptosis
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